Bumsoo Han

For More Information

• Bumsoo Han Research Group

Education

• PhD, Mechanical Engineering, University of Minneosta, 2001
• MS, Mechanical Engineering, Seoul National University, 1996
• BS, Mechanical Engineering, Seoul National University, 1993

Biography

Bumsoo Han is Professor of Mechanical Science and Engineering and Phil & Ann Sharp Scholar in Cancer Research. Prior to joining the University of Illinois, he has been Professor of Mechanical Engineering and Biomedical engineering at Purdue University. He was also the Program Leader of the Drug Delivery and Molecular Sensing Program of the NCI-designated Purdue Institute for Cancer Research. He received his PhD in Mechanical Engineering from the University of Minnesota and his MS and BS from Seoul National University in Korea. After his PhD, he was a Postdoc Fellow in Mechanical and Biomedical Engineering at the University of Minnesota. He received US DOD Postdoctoral Award for Breast Cancer Research, NSF CAREER Award, US AFOSR Faculty Fellowship (Predictive Toxicology), and Richard Skalak Best Paper Award from the ASME Journal of Biomechanical Engineering. In addition, he is a Fellow of ASME.

Academic Positions

• Professor, Mechanical Science and Engineering, University of Illinois Urbana-Champaign, 2024-present
• Phil and Ann Sharp Scholar, Cancer Center in Illinois, University of Illinois Urbana-Champaign, 2024-present
• Professor, Materials Research Laboratory, University of Illinois Urbana-Champaign, 2024-present
• Professor, Institute of Genomic Biology, University of Illinois Urbana-Champaign, 2024-present
• Professor, Bioengineering, University of Illinois Urbana-Champaign, 2024-present
• Affliated Faculty, Beckman Institute, University of Illinois Urbana-Champaign, 2024-present
• Professor, Mechanical Engineering and Biomedical Engineering, Purdue University, 2016-2024

Other Professional Employment

• Visting Scientist, Micro/Nano Processing Group, Korea Institute of Industrial Technology, 2015
• Faculty Fellow, Predictive Toxicology Program, US Air Force Research Laboratory, 2013

Research Statement

Bumsoo Han's broad research interests are in biotransport phenomena for cancer research and tissue engineering. His current research is focused on drug transport at the tumor microenvironment, engineered microphysiological systems, and cell-matrix interaction in the stroma tissue. In addition, his group is developing 3D printing and microfludics techniques for biomanufacturign. His research contributes to drug discovery and cell/tissue engineering for treatment and prevention of cancer and brain diseases.

Research Interests

• Cellular and Molecular Transport
• Mechanobiology and Biomechanics
• Microfluidics
• Pancreatic Cancer
• Blood-Brain Interface

Selected Articles in Journals

• H. Moon*, Y. Du*, S.R. Choi*, S. Seo, C. Cheng, B.D. Elzey, J.H. Choi† and B. Han†, 2025, “DNA origami-cyanine nanocomplex for precision imaging of KRAS-mutant pancreatic cancer cells." Advanced Science, 2410278. (* equal contribution, † co-corresponding authors, Selected in Hot Topic: Microfluidics)
• C. Cheng, N. Deneke, H. Moon, S.R. Choi, N. Ospina-Munoz, B.D. Elzey, C.S. Davis, G. T-C Chiu, and B. Han, 2023, "Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture," Materials Today Advances, vol. 19, 100408.
• Y. Shen, S. Yuk, S. Kwon, H. Tamam, Y. Yeo and B. Han, 2023, "A time-scale guided microfluidic synthesis of tannic acid-FeIII network nanocapsules of hydrophobic drugs," Journal of Controlled Release, vol. 357, pp. 484-497.
• H. Moon, S. Saha, A. Mugler and B. Han, 2023, "Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues," Lab on a Chip, vol. 23, pp. 631-644. (Selected as Lab on a Chip HOT Article)
• C. Cheng, Y.J. Moon, J.Y. Hwang, G.T-C Chiu, and B. Han, 2022, "A scaling law of particle transport in inkjet-printed particle-laden polymeric drops," International Journal of Heat and Mass Transfer, vol. 191, 122840.
• S.M. Venis, H. Moon, Y. Yang, S.M. Utturkar, S.F. Konieczny, and B. Han, 2021, "Engineering of a functional pancreatic acinus with reprogrammed cancer cells by induced PTF1a expression," Lab on a Chip, vol. 21, pp. 3675-3685. (Selected as Cover Article)
• H. Moon*, A. Ozcelikkale*, Y. Yang, B.E. Elzey, S.F. Konieczny, and B. Han, 2020, "An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations," Lab on a Chip, vol. 20, pp.3720 - 3732. (* equal contribution) (Selected as Back Cover Article)
• M.J. Bradney, S.M. Venis, Y. Yang, S.F. Konieczny, and B. Han, 2020, "A biomimetic model of heterogeneous invasion in pancreatic ductal adenocarcinoma," Small, 1905500.
• J. Varennes, S. Fancher, B. Han, and A. Mugler, 2017, "Emergent versus individual-based multicellular chemotaxis," Physical Review Letters, vol. 119, 188101.
• A. Ozcelikkale, K. Shin, V. Noe-Kim, B.E. Elzey, Z. Dong, J-T Zhang, K. Kim, I.C. Kwon, K. Park, and B. Han, 2017,"Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model," Journal of Controlled Release, vol. 9, pp. 129-139.
• A. Ozcelikkale, H. Moon, M. Linnes, and B. Han, 2017, "In vitro models of tumor microenvironment to screen transport of drug and nanoparticles," WIREs Nanomedicine and Nanobiotechnolgy, Vol. 9, e1460. (Selected for Cover Image, and Top 20 Most Downloaded Papers)
• B. Han, C. Qu, K. Park, S.F. Konieczny and M. Korc, 2016, "Recapitulation of complex transport and action of drugs at tumor microenvironment using tumor-microenvironment-on-chip," Cancer Letters, vol. 380, pp.319-329.
• B. Kwak, A. Ozcelikkale, C. S. Shin, K. Park, and B. Han, 2014, "Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip," Journal of Controlled Release, vol. 194, pp.157-167.
• B. Han, W.L. Hanson, K. Bensalah, A. Tuncel, J.M. Stern, and J.A. Cadeddu, 2009 "Development of quantum dot-mediated fluorescence thermometry for thermal therapies," Annals of Biomedical Engineering, vol. 37, pp.1230-1239. (Highlighted on Nanotech News of National Cancer Institute (NCI) Alliance for Nanotechnology in Cancer)
• B. Han, J.D. Miller, and J.K. Jung, 2009, "Freezing-induced fluid-matrix interaction in poroelastic material," Journal of Biomechanical Engineering, vol. 131, 021002: 1-8. (Selected for Richard Skalak Best Paper Award)

Honors

• Biohub Investigator, Chan Zuckerberg Biohub Chicago, 2024
• Fellow, American Soceity of Mechanical Engineers (ASME), 2020
• Purdue University Faculty of Excellence Early Career Research Award, 2015
• US AFOSR Summer Faculty Fellowship, 2013
• NSF Faculty Early Career Development (CAREER) Award, 2008
• US DOD Postdoctoral Traineeship Award, Congressionally Directed Medical Research Program, 2003

Teaching Honors

• Purdue University Outstanding Engineering Teachers (2019)

Research Honors

• Purdue University Discovery in Mechanical Engineering Award (2018)
• BP Korea Fellowship (2015)
• ASME NEMB Outstanding Paper Award (2013)
• Purdue University Discovery Park Fellow (2013)
• Purdue University Seed for Success Award (2012)
• ASME Richard Skalak Best Paper Award (2010)