Cell/Matrix Mechanobiology: current state and future directions

October 26-28, 2015
 
University of Illinois at Urbana-Champaign
 
Workshop theme: Considerable experimental evidence acquired during the last three decades has now established that extracellular biophysical cues, such as forces and matrix stiffness, have a profound influence on a wide range of cell behavior such as growth, motility, differentiation, apoptosis, gene expression, adhesion and signal transduction. More recently, it is appreciated that cells not only respond to these cues from the matrix, but also remodel the matrix and hence influence the subsequent cues. This dynamic reciprocity gives rise to an emergent property of the cell/matrix system, and they co-evolve with time. This is particularly prevalent in embryogenesis, development and tumor growth. The precise role of mechanics in determining this reciprocity remains elusive. [Read more.]
 
Steering committee:
Taher Saif (Chair, UIUC), 
Paul Janmey (Co-Chair, U Penn), 
Daniel Fletcher (UC Berkeley), Krystyn Van Vliet (MIT), Viola Vogel (ETH Zurich), and Patricia Bassereau (Institute Curie) 
 
Local (UIUC) organizing committee:
Ning Wang, Iwona Jasiuk, Joon Kong, Rashid Bashir, William Brieher, Sascha Hilgenfeldt 
 
Confirmed off campus (UIUC) participants:
Tejal Desai (UCSF)
Dennis Discher (U Penn)
Adam Engler (UC San Diego)
Peter Friedl (Radboud University Nijmegen, Netherlands and MD Anderson)
Margaret Gardel (U of Chicago)
Jochen Guck (Technische Universität Desden, Germany)
Rakesh Jain (Massachusetts General Hospital, Harvard Medical School)
Cynthia Reinhart King (Cornell)
Roger Kamm (MIT)
Gijsje H. Koenderink (Universiteit Amsterdam)
Sanjay Kumar (UC Berkeley)
L. Mahadevan (Harvard)
Tim Mitchison (Harvard)
David Mooney (Harvard)
Sam Safran (Weizmann)
Mike Sheetz (Columbia and Mechanobiology Institute, Singapore)
Vivek Shenoy (U Penn)
G.V. Shivashankar (Mechanobiology Institute, National University of Singapore)
Marvin Slepian (University of Arizona)
Yu-Li Wang (Carnegei M)
David Weitz (Harvard)
Denis Wirtz (Johns Hopkins)
Mingming Wu (Cornell)
Muhammad Zaman (BU)
Cheng Zhu (Georgia Tech)